Biochemist (m/w/d)

Tacalyx is a biopharmaceutical company developing innovative therapeutics to target tumor-associated carbohydrate antigens (TACAs). To strengthen our team in Berlin-Adlershof, we are seeking an experienced, enthusiastic, and self-motivated Scientist - Antibody and Protein Biochemistry. This laboratory-based role focuses on the design, expression, purification, characterization and modification of antibodies and recombinant proteins to support therapeutic development. It also includes the coordination and scientific oversight of external research activities.

Scientist (m/f/d) -

Antibody and Protein Biochemistry

Full-time | On-site in Berlin-Adlershof

Design of protein and antibody constructs, including chimeric, humanized and multispecific mAbs

Chemical and enzymatic modification of antibodies (e.g. fragmentation, labeling and conjugation)

Characterization of antibody affinity, integrity, activity and stability using methods such as SPR, ELISA, Western blotting and thermal shift assays

Molecular cloning and expression of recombinant proteins in prokaryotic and mammalian cells

Development and implementation of protein purification workflows using an ÄKTA chromatography system

Documentation and reporting of results and evaluation of relevant scientific literature

Collaboration in project teams advancing antibodies toward first-in-human studies

Coordination and scientific oversight of projects with external partners (e.g. CROs, academic groups)

Essential qualifications:

PhD in biological sciences or a related discipline, with substantial hands-on laboratory experience

Strong expertise in antibody and protein biochemistry, including cloning, expression, purification and analytical characterization

Practical experience with protein chromatography and biochemical assays

Strong communication skills in English

Preferred qualifications:

Relevant postdoctoral or industry experience

Proficiency in protein and antibody construct design

Skills in HPLC-based method development

Practical expertise in SPR-based measurements of binding kinetics and affinity

Familiarity with antibody humanization

Knowledge of carbohydrate biology

A permanent, full-time position with a competitive salary and excellent opportunities for professional and personal development

A diverse, international workforce with a dynamic working environment that fosters creativity, innovation and teamwork

The opportunity to contribute to antibody programs advancing toward first-in-human studies

A performance-based annual bonus

Regular company and team events

A fully employer-funded public transport pass (“Job Ticket”)