Biologe (m/w/d)

The University Medical Center Göttingen (UMG) unites the Medical Faculty of the Georg-August University and the University Hospital in an integration model. With around 9,700 employees, the UMG and its subsidiaries are one of the largest employers in the region. Our clinics and institutes stand for high-quality patient care, excellent research, modern teaching and transfer of innovative technology.

Göttingen as a city of science is located in the center of Germany and the University Medical Center Göttingen is integrated into an attractive network of university and non-university scientific institutions.

The Klinik für Kinder- und Jugendmedizin of the University Medical Center Göttingen is looking for a new position for the earliest start date

Postdoc (f/m/d)

full time , initially limited to 31.05.2027

Remuneration according to TV-L

We are seeking a motivated researcher to investigate the molecular pathophysiology of lysosomal and related neurodegenerative diseases and to contribute to the development of novel therapeutic approaches. Lysosomal diseases are rare, neurometabolic disorders that often manifest in childhood or adolescence. Despite their genetic heterogeneity, many share converging molecular mechanisms that overlap with ical adult-onset neurodegenerative diseases. These disorders affect both the nervous system and peripheral organs and are clinically characterized by progressive symptoms and cognitive decline. As casual therapies remain unavailable for most lysosomal diseases, this field offers a unique opportunity to drive discoveries with direct translational impact. Our research group focuses on the molecular characterization of both genetically defined and poorly understood lysosomal diseases, aiming to understand cellular pathology and develop therapeutic strategies. We work with patient-derived cells and human cell models, applying high-throughput techniques such as drug screening to accelerate discovery.

Investigate the molecular mechanisms and organelle pathology underlying lysosomal diseases (endo-lysosomal trafficking, autophagy, secondary mitochondria disruption)

Apply and integrate multi-OMICS (transcriptomics, proteomics, metabolomics) approaches to identify dysregulated intracellular pathways and identify therapeutic targets

Validate targets using genetic and pharmacological perturbations (CRISPR/ Cas9, small molecules) with quantitative functional readouts (enzyme activity, lysosomal flux, imaging)

Maintain and characterize patient-derived fibroblasts and iPSC models; implement disease-relevant phenotypic assays

Develop and automate high-throughput compatible assays for drug repurposing screenings; analyze hits and lead follow-up studies

Collaborate across our Göttingen network; document, present, and publish results; and contribute to reproducible workflows and data sharing initiatives

PhD (completed or near completion) in life sciences (e.g., biology, molecular medicine, biochemistry) or a related discipline

Strong hands-on background in molecular and cell biology with an interest in translational medicine

Experience in gene editing, multi-omics data integration, basic program ming, or advanced imaging is desirable

Experience with high-throughput/automation and stem cell (IPSC) models is an advantage, but not mandatory, as these skills can also be developed during the project

High self-motivation, an independent and creative working style, and excellent teamwork and communication skills

A collaborative neuroscience and translational research environment at the University Medical Center Göttingen (UMG), DZKJ, and Fraunhofer ITMP, with close ties to leading institutions such as the Max Planck Institute for Multidisciplinary Sciences and the DZNE

Extensive opportunities for interdisciplinary exchange, joint projects, and direct links between basic and clinical research through local, national, and international collaborations • Secure, multi-source funding (UMG, E...